Effects of Probiotic on Insulin Resistance in Gestational Diabetes Mellitus

What is Gestational Diabetes Mellitus?

Gestational diabetes mellitus (GDM) is a condition that some pregnant women get. This happens when the pregnant woman’s body can’t use sugar (glucose) as well as it should. This can cause problems for the mother, the baby, and even the newborn baby.

What Are Some of the Risks Associated with Gestational Diabetes Mellitus?

There are many risks associated with Gestational diabetes mellitus, including pre-eclampsia, unplanned cesarean delivery, macrosomia, birth trauma and neonatal hypoglycemia.

Can Probiotics Help to Control Gestational Diabetes Mellitus?

Some studies have shown that probiotics may be helpful in controlling Gestational diabetes mellitus. However, more research is needed in this area. 

The purpose of this study was to evaluate the effects of probiotic supplements on metabolic parameters, including fasting glucose and insulin resistance, in pregnant women with GDM in Thailand.

The Study on Probiotic Supplements for Pregnant Women Diagnosed with Gestational Diabetes Mellitus

A double-blind clinical trial was carried out on women 18 to 45 years old, at 24 to 28 weeks of pregnancy, and with diet-controlled gestational diabetes mellitus. All have no history of chronic diseases like immunodeficiency, hypertension, pre‐gestational diabetes, kidney disease, or liver disease.

The participants were randomly assigned into two groups: one received the probiotic supplement Infloran® in capsule form, containing 1000 million colony-forming units (CFU) Bifidobacterium bifidum and 1000 million CFU Lactobacillus acidophilus, while the other had the gelatin-containing placebo. These capsules were taken once per day for four weeks. Primary outcomes were average differences in fasting plasma glucose, insulin resistance, and fasting insulin between the two groups. Secondary outcomes were changes in the mother’s weight after the intervention.

Nutritionists provided the participants with a diet-control plan that modified their daily caloric intake, including the amount of carbohydrates, fat, protein, and fiber they were to consume during the four-week intervention period.

The Results

Analysis of the data from 28 patients in the probiotic group and 29 in the placebo group showed a significant improvement in the glucose metabolism of those in the probiotic group, including fasting plasma glucose, fasting plasma insulin, and insulin resistance. There was no significant difference in the weight gain between the two groups. 

In addition, probiotic supplementation was well tolerated and safe in the participants.

The Conclusion

Women with diet-controlled gestational diabetes in their late second and early third trimester of pregnancy tend to have lower fasting glucose, decreased fasting insulin, and increased insulin sensitivity when given probiotics for four weeks. Probiotic supplements may help control blood sugar in these patients.


Effects of Probiotic Supplements on Insulin Resistance in Gestational Diabetes Mellitus

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