How Clostridium Difficile Infection May Be Fully Cured | Probiotics For Gut Health

What is Clostridium Difficile?

Clostridium difficile is a bacteria that causes over 450,000 infections and 15,000 deaths every year in the U.S. Treatment for this infection is a big challenge. About 25-30% of people treated for a primary infection will have a recurrence.

Clostridium difficile can cause infections in the gut when there is a disruption in the normal bacteria. Probiotics are good bacteria that can help keep you healthy. They travel through your gut and can provide some protection.

Is Probiotics an Effective Treatment for Clostridium Difficile?

Meta-analyses of randomized controlled trials (RCTs) have shown that taking specific probiotic strains during antibiotic therapy can significantly reduce the risk of developing a CDI.11-14 

However, there are no studies that look at the effectiveness of probiotics as treatment during an initial CDI episode. So we did a pilot RCT to see if adding daily probiotics as an adjunct therapy to standard antibiotic treatment would help participants with an initial CDI. 

We thought that, compared to taking a placebo, adjunct probiotics would lead to a shorter duration of C. difficile diarrhea and a reduced likelihood of CDI recurrence.

The Study Of Using 4 types Of Probiotics On Clostridium Difficile

The study gave people a probiotic pill every day for 28 days. The probiotic had 4 different types of bacteria in it: 

  • Lactobacillus acidophilus NCFM
  • Lactobacillus paracasei Lpc-37
  • Bifidobacterium lactis Bi-07
  • And B. lactis Bl-04

The people who took the probiotic pill did not have any more diarrhea than the people who took the placebo pill.

The Result

The result of the study was that the probiotic therapy was linked to a significant decrease in the number of days that a person had diarrhea, as well as a decrease in the number of days of diarrhea per week.

The Conclusion

Probiotics may help people with the first case of CDI. They should be studied more in a bigger test.


A Randomized Controlled Trial Of Probiotics For Clostridium Difficile Infection (PICO) In Adults

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