Parkinson’s Disease | Probiotics improved Constipation and Gut motility

What is the common symptom of Parkinson’s disease?

Constipation is a common problem in people with Parkinson’s disease. This is a condition caused by a chemical in the brain called alpha-synuclein. This chemical can cause problems with the muscles in the gut leading to issues with moving food through the intestines which can cause constipation. 

What is Probiotics and Can it Improve Constipation

Probiotics are bacteria that are good for the gut. There is some evidence that probiotics can help improve constipation in people with Parkinson’s disease. They can help to improve gut movement and reduce pain and bloating. Probiotics can also help to improve the overall symptoms of Parkinson’s disease.

This study was conducted to see the efficacy of a multi-strain probiotic combined with prebiotic fiber (fructooligosaccharide) compared to placebo, on constipation symptoms and intestinal motility, in PD patients with constipation.

The Study on Constipation and Probiotics

PD Patients with constipation (those who met the ROME III criteria) were randomly given a multi-strain probiotic (containing Lactobacillus sp and Bifidobacterium sp at 30 billion CFUs) with fructooligosaccharides or a placebo (fermented milk) twice a day for 8 weeks. 

The main outcome of the study was whether or not the probiotic helped to improve symptoms of constipation, as measured by the Garrigues Questionnaire (GQ), which includes an item on bowel opening frequency. Secondary outcomes were gut transit time (GTT), quality of life (PDQ39-SI), motor (MDS-UPDRS), and non-motor symptoms (NMSS).

The Results

55 participants were recruited for the study, 48 of which completed it. 22 people took a probiotic and 26 took a placebo. At 8 weeks, The probiotic group had a higher average amount of BOF (Bowel opening frequency) each week than the placebo group. Patients in the probiotic group were five times more likely to have a higher BOF (Bowel opening frequency)  than those in the placebo group. The GTT in the probiotic group reduced significantly compared to the placebo group.

The Conclusion

Study showed that taking Hexbio, a probiotic with multiple strains, over 8 weeks improved bowel opening frequency and whole gut transit time in people with Parkinson’s disease who had constipation.


Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: A randomised controlled trial

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