Probiotics is Effective on Childhood Diarrhea by Altering Gut Microbiota

What is Acute Diarrhea?

Acute diarrhea is a significant cause of sickness common in young children and adds to expenses for families. 

A virus, bacteria, or parasite can cause acute diarrhea, leading to gastroenteritis, bloody stool, or a more severe infection in the abdomen. 

Can Probiotics help in reducing the symptoms of Acute Diarrhea?

The goal of this study was to see if probiotics could help improve symptoms and the bacteria in the intestines, and treat infection during diarrhea.

The Study Method on Probiotics for Acute Diarrhea

The study involved 81 children hospitalized for acute diarrhea, aged six months to six years. Of the 81, 42 were chosen randomly and were given probiotics of Lactobacillus casei variety (Lc) orally twice daily for seven days. The other 39 children were placed in the control group where no probiotics were given.

Feces samples were collected to see the types of microbes present.

Immunoglobulin A (IgA), lactoferrin, and calprotectin were measured in all the patients from both groups using a machine. IgA plays an important role in protecting one against infections. Lactoferrin and calprotectin are reliable indicators for inflammation.

Other signs and symptoms were also observed:

  • Fever
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Bloated abdomen
  • Daily intake
  • Appetite
  • And body weight

The Results

Data was collected from the 81 children over three different time points. Those who took probiotics had a significantly higher total amount of IgA in their feces and had significantly lower levels of lactoferrin and calprotectin than those in the control group. This suggests that taking probiotics may be beneficial for gut-microbiota modulation.

The number of Bifidobacteria and Lactobacillus species was higher in the stool culture of people who took probiotics than those who did not. People who took probiotics felt better overall – they had better appetites, gained more weight, had less abdominal pain and bloating, and had fewer bowel problems (like diarrhea)

The Conclusion

Fecal analysis showed increased IgA when the patients took the Lc probiotic; in contrast, lactoferrin and calprotectin decreased. Probiotic Lc may be a helpful supplement for children during acute diarrhea to reduce their symptoms and lessen the inflammatory reaction on their intestines.


Probiotic Lactobacillus casei: Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers

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