The Benefits of Probiotics for the Treatment of Bacterial Prostatitis

What is Bacterial Prostatitis?

Prostate inflammation, pain, and urinary symptoms are some common problems that can happen with prostatitis. This condition is often caused by bacteria, and it can be very aggressive. Men who have had prostatitis in the past are at high risk for recurrence- about 20% to 50%. Oxidative stress plays a big role in prostate inflammation in men. For women, other things might cause inflammation, like the mouth or gut. As inflammation gets worse, areas of damage form, which makes it difficult to pee and increases the chances of getting infected again. Most cases of prostate infection are caused by bacteria. The most common germs are Gram-negative bacteria like Escherichia coli (E.coli), Enterococcus faecalis (E. faecalis), Klebsiella, Pseudomonas, and Proteus species. But there’s also a chance of getting infected with Gram-positive bacteria like Enterococcus. Research has also found that men with chronic prostatitis have lower seminal lactobacilli levels than healthy men. This is because they often take antibiotics.

Can Probiotics Reduce the Risk of Infection in Prostatitis Patients?

Antibiotic treatment of prostatitis is not always effective on its own. Adding probiotics may help restore the healthy bacteria in your gut and reduce the risk of infection

The benefits of probiotics for the treatment of bacterial prostatitis have been shown in human clinical research. One study looked at the effects of probiotic supplementation alongside antibiotics for the treatment of chronic bacterial prostatitis. A growing amount of research supports the theory that probiotics can help prevent recurrent infections in men, especially Lactobacillus strains. 212 men with chronic bacterial prostatitis were randomly assigned to two groups: one group with the only antibiotic as the cure, the other group with more probiotic antibiotic treatment. The cure was followed for 30 days. At the end of the study, 27.6% of the group that received only antibiotics had a recurrence of urinary tract infections, while only 7.8% of the combination group had a recurrence. Recent evidence has shown that the urinary microbiome is implicated in inflammation of the prostate and in possible tumor onset mainly due to its anatomical proximity and the potential of the urinary tract to act as a transport vehicle for contamination by external microorganisms. The urinary microbiome has also been shown to have peculiar compositional characteristics that distinguish it from the skin of the adjacent genital areas and to be substantially different between males and females. In detail, the male urinary microbiota was mainly formed by Corynebacterium, Staphylococcus, Streptococcus, Anaerococcous, Finegoldia, Lactobacillus, Peptoniphilus, Enterobacteriaceae, Pseudomonas, Actinobaculum, Gammaproteobacteria, and Actinomyces. It is interesting to note how it partially changes with age. Probiotics can protect against harmful bacteria and restore the loss of bacteria that support health lost during treatment with antibiotics. This makes probiotics one of the best treatments for bacterial prostatitis. Probiotics have been found to have interesting activity in several gender-related diseases. Preclinical studies indicate that an optimal diet and use of probiotics after pelvic cancer and during radiotherapy may be able to prevent radiation-induced survivorship diseases. Lactobacillus acidophilus, Lactobacillus fermentum, and Lactobacillus plantarum seem to be useful in chronic or relapsing infections, often able to trigger neoplastic onset. Lactobacillus strains induce TRAIL production and facilitate natural killer activity against cancer cells: tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous cytokine that induces apoptosis in malignant tumor cells, including gastrointestinal tumors. Moreover, Curcumin is a botanical with anti-tumor and immunomodulatory properties.

The Study Method on Probiotics as a treatment for Prostatitis

20 Healthy men aged 55-65 years old were enrolled in a study. They were randomly divided into two groups. Urine culturing was done to see if they had any Enterobacteriaceae (Escherichia Coli and Enterococcus faecalis) at the beginning of the study and at 12 weeks later.

The Results

Taking probiotics reduces the number of E. coli and E. faecalis bacteria in urine cultures. The probiotic did not affect the weight change in the study subjects who had inflammation.

The Conclusion

Data confirms that taking probiotics is important for people with prostatitis.


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